Any momentum the Express gained by winning the last two games of the first half of the season ended after one inning.
Round Rock took an early two-run lead in its first game after the All-Star break Thursday night on the road in Memphis, but the Redbirds responded with three runs in the second inning and pulled away for a 6-2 win.
Tyler Wagner (1-8, 7.28) pitched six innings, allowing three runs on seven hits with two strikeouts and four walks.
Offensively, the Express had just three hits and struck out 11 times and had two baserunners in the final eight innings.
Jurickson Profar walked in the first inning and Brett Nicholas, one of two Round Rock players named to the PCL All-Star team, drove him in with a double to right field. Jared Hoying singled with two out to double the lead.
Memphis responded n the second inning with back-to-back two-out singles. Patrick Wisdom — who is tied for fifth in the league with 18 home runs — then blasted a three-run home run. It was the 16th long ball Wagner has allowed this season, the most on the Express pitching staff.
Drew Stubbs singled in the sixth inning for the only other hit of the game for Round Rock. But the flame was quickly snuffed out when Profar hit into a double play and Nicholas ground out to second.
The Redbirds immediately jumped on Sam Wolff in the seventh, tagging him for three runs and four hits and extending their lead to 6-2.
The loss puts the Express at 41-50 on the season, 16.5 games behind the Redbirds for the American Southern Division. Round Rock trails Nashville by two games for second place in the division.
Round Rock and Memphis continue the four-game series Friday at 7:05 p.m. The Express return home on Monday to begin a four-game series against the New Orleans Baby Cakes at Dell Diamond.